Thursday, December 30, 2010

The year that Was... The Most Awesome Year yet

On a High after giving the Dec2009 CSIR when we all got back to Pune in Jan, all the whole of bioinfo batch wanted to do was: Masti. January seemed to be dedicated to it. The batch went to an overnight trip to Vasota. Considered by far the best by many, not me though. The guys next went to Purandar Fort. One of the cheapest and definitely the most spontaneous of our treks. Not satisfied yet, our next trek was to Dhak Bhairi. The most toughest trek ever and that is a unanimous opinion. By now we all had got our guides and projects. Buried somewhere within the GBs of Pics that we took, was our Literature Review which we were supposed to be doing. But hell May was far off, who cared about the project anyways? :)
Next came Feb. We took the first Sunday off from trekking. Bad decision: in the evening we guys got robbed at gunpoint by Somya at Chatuhshrungi. What a start to the month. Bloody ended every damn plan prematurely, before we even thought of it. It was a bad bad experience. Well in any case it put an end to all our masti. Everyone came right back to their ground states, I infact went into an underground state not being able to bear the loss of my Corby!! Feb went off with rounds of police stations, people, contacts, hell we even got to talk to Somya through a contact in a desi bar. Said he had sold our phones coz he needed 2 laks.
March came and i applied for my passport. On Holi the good news came that Somya had been caught by the police and they had recovered our phones. Man the joy and happiness of it all. That was a gr8 holi! Like the first Fri of every month, this one had already been taken up by Wangikar Sir. I had a lot of preliminary data processing to do. On top of this the police tells us to get orders from the courts to get back the phones. March went in courts and coding.
April started and i started to actually code on the real algorithm of my project. I thought I could finish it in 2 weeks. The rounds of the courts and police stations continued. I kept on coding. I took a whole month to write down 750 lines of code and it ran terribly. It was slow, it was buggy, it was bad coding. By mid april i was supposed to get my passport. But Hell it had gotten stuck in the Police Stn! More rounds of Police Stn then. But we got our cell phones back finally :)
With May the temperatures started getting really oppressive in the Lab. I Optimized my code so that it ran like a sports-car. It was lighter - 450 lines and faster. Time had come to run it on my whole dataset. This was also the time when all my interviews were gonna take place and the sem end theory and practical exams were scheduled as well with the Project presentations. Unfortunately the class performance was so bad that the project presentations were shifted to Jun end. Which was good :) May was a crazy crazy month. I literally jet setted my way about Mumbai Pune and Bangalore for PhD interviews. Whats worse is that i failed in all of them :(
June: I finished up whatever was my project. The results turned out to be bad unfortunately. Next scheduled was a trip to Bangalore for IISc interviews. This was a do or die moment for me. The story of how i did it is for another time and place but point is i DID it :) After that when i came back to Pune for the Project Presentations there was just no looking back. I had gotten the passport cleared as well by "donating" stationary to the police stn passport office. But atleast i did not have to pay money upfront in this corrupt country of mine! June ended MSc ended, a chapter of my life closed, a part of me remained back in Pune, the rest of me walked on.
July was the Month of Meeting Everyone. Met all the old friends. Relaxed at home cause the future was secured in IISc. July 28th touched Bangalore! New chapter started!
August. New place, new people, new food, heck even new clothes thnx to mums insistence. Pankaj was the only thing I already knew about IISc and am glad he was there. Made new Friends. Realised that again I had got a gr8 batch. Went for trips. Weekends at Ashwins. Exploring Bangalore. Meeting up with long lost childhood friends in a city stranger to all of us. The best Freshers ever!
September, broke the shell completely, lost control completely, exams came, i failed completely! On top of that personal complaints against me by A**HOLE profs with bloated egos coz of plugged A**HOLES. Was a bad time towards the end. To the rescue came Friends from Pune. It was time to go back to my roots. Go to a place where i could just be me. Turned out the name of that place was Urli Kanchan, a small village 35km from Pune off the Pune-Solapur Highway.
October: thats how it started, In Urli Kanchan. One of the most unforgettable nights ever. The night was crazy. No other word for it. 7 bikes, a field, more than 6 kilos of food, liters of a potent drink, 5 deg Cel, one small bonfire and 11 guys. After I came back from Pune I knew everything was gonna be just about fine.
November came and with that exams. Ones which I couldn't fail, infact a few in which I had to do exceptionally well. A month of some cold calculations and hard work regarding exams. A month also of the One Plunge taken with the eyes closed without gauging how high the fall was, how deep and cold the water was. And mid Nov! a gamble which paid off. Probably an event which has already changed my life forever ahead! Exams came in, I just gave em. And the ones in which i needed to, I just DID. Again!
Dec: This month had FAMILY written all over it and that too in BOLD! Came back home. Drove to Ahemdabad in the brand new SX4. The best car i have driven till date surely! Came back drove to Mahabaleshwar. Relieved some of the FYBSc Botany memories. This was the most offbeat vacations with the family. And now in the wee hours of the last day of this great great year, this blogpost.

Next Year: Jan is gonna start with a Bang called Honda Dazzler! Life is gonna be sweet. And like Calvin says: The Days are Just Packed!

Friday, December 3, 2010

Cocktails and Dreams

I have no idea why I put that as the title. Except that theres a feeling associated with that phrase. Its from the Movie Cocktail starring Tom Cruise in which he is a bar tender and he dreams of opening his own bar one day; which he does eventually and names it 'Cocktails and Dreams'. The phrase has always evoked a success-content-happiness-bliss kinda feeling. The kind I am feeling now. Life has become one long stretch of euphoria interspersed with satisfaction and I am gonna savor it for as long as it lasts.

1st sem in IISc, the first 4 months have been a whirlwind of course work, assignments, exams, failures, successes, late nights, early morning boring lectures, new friends, movies in library, dominoes orders, tp with tp gang, CSIR jhol and what not.

I have started getting my stipend. Will buy my own bike next Jan. Hopefully. Finally.

Life next year is gonna be just awesome.

I realised i have never blogged about IISc before. Maybe sometime later i'll tell the story of how i made it to IISc.

Friday, October 29, 2010

Maruti Omni-E 1998 (Dec-14)

First Day: It was a saturday (I think) and Sis had won some competition in school (extempore?), Mom had a half day, I was at home as well, Dad comes in, says : Lets go for a drive..! And we were like - in whose car? And he says he just bought a new car!! Hellooo??!!! :D

And tomorrow that car is gonna move on to its new owner, a car dealership.

I don't know what to say, feeling really melancholic about it.

When we bought the Omni, we were the only people I knew who had a Van. Mom was always asking WHY are we buying an EIGHT seater vehicle which is most commonly seen as a taxi? She still doesn't know the answer, but am sure she stopped caring long back.

There have been so many events where that car was central to the outcome.

I still remember the day when Dad had beat the shit outta me when I had refused to wash the car. And the time when he drove it like Schumi from Ruia to Colony because I had forgotten my documents before admission.

The trip to Goa - dad drove all the way alone, no other car could have been more comfortable with the space we had. The trip to Nagaon with JD, Kamlesh. And to Lonavala with JD, Kamlesh and Vidhi.

It was the car in which I learnt to drive. Dad taught me. I had none of the Balaji Motor Driving School bullshit. First Lesson, lasted for 15 min. I learnt - start the car, put it in first gear, move ahead, stop, put it in reverse gear, go back, stop. That's it. Definitely come a long way since. Guess I passed my driving the test when I drove the family back from Nagaon on a learners license.

Ferrying all the relatives from Dadar and Churchgate Stn to colony. Driving to Kharghar to see our new home under construction. Picking up Sis and her friends from the Stn everytime it was raining. I remember a crazy drive in a flooded Belapur when the water was so high all brakes failed and the floor carpet had gotten wet. The drive from Kharghar to Colony when the engine overheated near Nerul. The one time it punctured the tyre near Sion Circle.

It may have been a grossly under powered car, with bad suspension and huge body roll and no AC and whatever. For all its worth it was a car which always delivered what was asked of it. It was an awesome car. And apart from all this it gave our family 12 years worth of great memories.

Saturday, October 16, 2010

Water

We know it is important, we know it is crucial, we know it is indispensable and yet we remain irresponsible while using it.

I can harp on and on about how it is important to conserve water, make sure that potable water is available to all etc. etc. except that I fail to identify with anything that has to do with people anymore. I mean at least in India do what you want but people are just not gonna improve. Fine the government never really made dams or divert water to areas which are perennially under drought, but what did the people do? They are just as content making the women do the walking and getting the water.

What interests me though is the chemical itself. The molecule, their collection, its properties. For example I was left amazed that the IR spectra of pure liquid water is not yet explained. For a molecule which is so simple, this is mind boggling. And what about the very weird physical properties? Expands on cooling, expands on heating as well!!! Weird melting and boiling points and so on. And that too so neat 0 as freezing, 100 as boiling (is this coz of the scale itself?? I dunno!!)

But something of even more interest is the structure that liquid water has. The molecules are always in association with on another via hydrogen bonds and thus liquid water isn't just loosely packed water molecules but instead a proper dynamic lattice of water molecules. This has huge implications in protein folding. No one quite knows exactly how a protein folds and attains its native structure. I have a few ideas of my own on this, one of which involves lots of water molecules..!!

I guess like last year, my this years Blog Action Day post is also defeating its own purpose, but then if this has gotten me back to my old blog then the purpose is served, at least for me!

Monday, September 6, 2010

The Professor Index

I realized that very few people actually have the power to stop time in its very tracks..!! And all of them are College Professors.

But how do you quantitate the power of such people? So here is an index - The Professor Index, which is the ratio between Real Time : Apparent Time
Professor Index = Real Time/Apparent Time

Real Time is the duration for which the lecture was actually held.
Apparent Time is the time you thought the lecture went on for. Analogous to Feels Like Temperature.

The index is most accurately measured for a real time of 45 minutes because that is the average attention span of most individuals.

The higher the index the better is the professor.

Professor Index > 1 ---- Very Good -> Excellent -> AWESOME -> Start ur Own Religion
Professor Index = 1 ---- Good -> Fairly Decent
Professor Index < 1 ---- Bad -> Very Bad -> Pathetic -> Die -> Kill Me

This post was actually inspired by the man who is so powerfully strong in stopping time that his Index touches Avogadro's Number albeit in the negative power of ten.
Every morning from 9 onwards (till 10 real time) he stops time infinitely and I am left asking the question 'what am i being punished for??'.

Monday, May 10, 2010

Be the Maxwell's Demon

While reading up on Shannon's Entropy and Information Theory today I chanced upon the term "Maxwell's Demon". A term like this i find to be irresistible, so there I went to Wikipedia to read up and holy mother of god guess what did i find...??

Before venturing further allow me a discourse on Maxwell's Demon. The second law of thermodynamics states that the entropy of an isolated system, which is not in an equilibrium, will increase over time to reach a maximum when the system attains equilibrium. But why does this happen? According to Maxwell it was because of statistical improbability. Let me elaborate, suppose there is a container with an opaque, insulating partition in between. Both partitions are filled up with the same gas; however there is no way the gases can mix or temperature change because of the partition. If the gases are at different temperatures then they will remain in the same state because this system is defined to be an isolated system.

If there was a small hole in the partition then the gases would start to mix, there would be temperature exchange and before long the gases will be in equilibrium, as would be expected by anyone familiar with second law of thermodynamics. Now instead of gases being in different temperature start with a box in perfect equilibrium. But there's a small change - we are gonna introduce the Maxwell's Demon inside the box. He is a small creature who is the gatekeeper of the hole. And he has decided that fast moving molecules are allowed to enter one compartment but slow moving molecules are not. Slowly the Demon will filter all fast moving molecules to one side of box and slow moving molecules will be on the other side. This will increase the temperature on one side of box and reduce it on the other side, entropy of the system will decrease... poof goes 2nd law.

Coming back to holy mother of god exclamation, it struck me amidst all this that my Blog actually has a game which enables player to BE THE MAXWELL'S DEMON.

The "Separate the Green and Red" game has been rechristened "Be the Maxwell's Demon". Cause essentially it represents the system described by Maxwell and while it is not an exact representation of the system (regarding speed of molecule - here its the color), in essence it can very easily describe the concept!!

To think an exercise in rigid body simulation in java could turn out to be so similar to some totally different concept all together...!! What can i say : It really did happen to me...!!! :P

P.s. : Such real life Demons do exist. Think about Dialysis membrane, membrane proteins etc. But they are ALL pseudo demons, because the systems are not perfectly isolated and the act of separation causes entropy to increase elsewhere in the universe, most of these require energy in some form or the other.

Friday, May 7, 2010

Driving Forces of Evolution

What is the driving force of evolution??
What makes one species evolve into another??
Why does evolution occur??
Is it natural selection? or is it perhaps mutation?

The points below are what I understood after a bit of reading and thinking.

Natural Selection drives evolution. Since irrespective of the repertoire of different genes present in the gene pool, if one gene is not chosen above another gene (based on some criteria) then the relative frequencies of genes in gene pool will remain the same and consequently there wouldn't be any evolution.
So clearly some gene has to get selected over another, this selection criteria is called Natural Selection.

However for Natural Selection to work there must be sufficient diversity in the gene pool itself so that some or the other gene is good enough to pass the test proposed by selection. Thus rate of mutation also is a factor at driving evolution. Its observed that viruses mutate at a higher rate and (thus?) evolve at a higher rate too.

However, mutations can either make a gene better at passing the present selection test, or make it worse at it. If they make the gene worse then it will fail the test and disappear into oblivion. But generally mutations don't cause any significant change in the capability of a gene to pass a selection test. These 'neutral' mutations can accumulate to a large number over the span of time. Random drifts in such neutral mutations can result in some gene being replaced by another as result of random event. Might seem a little far fetched, but in the timescales that evolution works under its definitely plausible. And so random drifts in neutral mutations may drive evolution too.

Is there any bias for or against some particular mutation? Is it more likely for an 'A' to convert into 'G' or 'C' rather than a 'T'. Or for that matter any other combination of 'ATGC' in the above sentence. I don't know if such bias is proven, but this bias has been implicated as the reason for the observed GC content variations among closely related prokaryotic species.

Of course all these mechanisms are not mutually exclusive w.r.t gene or time. For different genes different factors would be responsible for evolution. But these forces probably are the reason why one species evolves into another with passage of time.

Friday, March 26, 2010

Censorship

Open your eyes, take a look around you and count the number of things you are restricted to do. Is the hoarding you are looking at torn? Is the movie theater closed? Is the image blurred? Now ask yourself, is it required that you be restricted??

Obviously I am not talking about laws or road traffic rules here. I am talking about censorship we are not even aware of being subject to. I am talking about the so called moral police who wish to control everything from images to ideas that we are exposed to, I am talking about the ban on books because it irked some narrow mind albeit with wide connections. I am talking about censoring of the internet search results, blocking of websites, search terms, word filters etc.

Who is anyone else to decide what should and should not be seen by you?? Ask yourself this question.

Monday, January 25, 2010

Dear Blog

I wrote the title spontaneously... perhaps because i have been feeling guilty. Feeling guilty that i haven't been paying much attention to the blog, that twitter and facebook have so totally side tracked the blog.

Its just that twitter is so straight forward and simple, u update from anywhere and its out there. Facebook on the other hand is so interactive. But i have always known that its the blog which will last, which will record and which will be read every time i feel nostalgic and want to reminisce. The fact that it can be vice-versa is just another feature... :)

So many things have happened since last post. 4th sem started, results good enuff. Got a good project under a good guide. Already went for two trips Vasota and Purandar (more on that later... ;) ). So i am pretty much relaxed; as i have always been, in MSc. No worries, no tension. Of course the future remains an open question, but somehow it doesn't bother me much, definitely not the way it bothered in BSc. I mean i am kinda used to it. In 10th they told me to rub my a** off so i get electronics. I opted for biology anyways (opted, since i didn't want electronics which i was getting btw). In 12th they told me to rub my a** off so i get engineering. I opted for BSc anyways. In BSc they told me to rub my a** off so i get a good MSc. I got not 1 but 3 good MScs. Now they tell me to rub my a**off for a good PhD. Well, there's not much left to rub anymore i guess. I know something will come along, that it will be good and what more do i want?? :)

I notice that i blog mostly when i am feeling happy. Perhaps when i read this in future i will only be reminded of the good things that took place. That's definitely a good thing, who wants to remember the bad things anyways. This blog was intended for only one reader, and this post, thus, is meant only for him. Cheers buddy!!!... :)